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Karl Fischer titration is a titration method that determines the amount of water (moisture) present in a given sample by using two different techniques, such as volumetric titration or coulometric titration. Many quality control applications require the determination of water content, including chemicals, pharmaceuticals, and food. Karl Fischer titration (KF) is a widely used quality control method that can meet the needs of various industries and research work. The oxidation reaction between iodine and sulfur dioxide is the fundamental principle of Karl Fischer.

Karl Fischer reagent contains iodine, sulfur dioxide, alkali, and solvents such as alcohol and anhydrous methanol, which are also used in the KF process.

Advantages of Karl Fischer titration:

The main advantage of Karl Fischer titration is that it can be used for volatile substances as well as non-volatile substances that are not possible in dry weight loss.

It is suitable for liquid, solid, and gas samples.

It provides higher accuracy and precision than other technologies.

A small amount of sample is needed to perform Karl Fischer's testing.

The Karl Fischer titration method is easy to operate and has a short analysis cycle.

It has an infinite measurement range from 1ppm to 100% of the sample.

The preparation of samples in Karl Fischer titration is very simple.

Suitable for automation; Different types of automation equipment can now be used.

It does not contain heat, so there will be no degradation, reaction, or sample loss.

It is allowed to use a spectrophotometer to visually identify the endpoint.